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Ashwagandha root in the treatment of non-classical adrenal hyperplasia.
Congenital adrenal hyperplasia (CAH) is a well-characterised family of disorders of the adrenal cortices, resulting in varying degrees of cortisol, aldosterone and androgen deficiency or androgen excess, depending on the enzyme(s) affected and the degree of quantitative or functional enzyme deficit. Withania somnifera (WS), commonly known as Ashwagandha, is a medicinal plant that has been employed for centuries in ayurvedic medicine. Preclinical studies have shown that WS increases circulating cortisol levels and improves insulin sensitivity. We report the case of a 57-year-old woman with non-classical adrenal hyperplasia due to both 3-ß-ol dehydrogenase deficiency and aldosterone synthase deficiency who was self-treated with WS for 6 months. After 6 months of treatment her serum 18-OH-hydroxycorticoserone, 17-OH-pregnenolone, corticosterone and 11-deoxycortisol decreased by 31%, 66%, 69% and 55%, respectively. The biochemical improvement was accompanied by a noticeable reduction in scalp hair loss.
BMJ Case Rep. 2012 Sep 17;2012. pii: bcr2012006989. doi: 10.1136/bcr-2012-006989. Kalani A, Bahtiyar G, Sacerdote A. Department of Internal Medicine, Woodhull Medical Center, Brooklyn, New York, USA.
>Many people have the inability to commit to others. This may be due to many reasons. For instance, they may lack certain social skills due to the failure for the part of their brain, which is involved with empathy and social skills, to develop fully. Also, a lack of nurturing early in life may cause them to be overly defensive.
Our brain is a learning machine that translates perceptions into patterns. In turn, this is reflected by neurological development. The social centers of the brain, which some scientists believe to reside in the lower areas of the parietal lobes, will become fully...
When considering the role of the mind and bodybuilding, two things quickly come up. First, a dedicated bodybuilder almost always already knows what is required to accomplish the desired state. Therefore, in order to accomplish their goals it is essential that they have the right mindset. Secondly, there is a theory that setting a body image in your brain will affect the ultimate outcome.
A bodybuilder knows that the by providing themselves with the right nutrition and rest while participating in the correct weight lifting regimen that they will most likely achieve the results for which...
According to the US Centers for Disease Control and Prevention (CDC), over 45 million people in the United States are currently smokers. While this is 19.3% of all adults, with the exception of Asians, smoking rates tend to be higher for African-Americans and Hispanics. Every day more than 3,800 people under the age of 18 smoke their first cigarette. About a quarter of them begin smoking regularly. In my experience working with people who are trying to stop their smoking habits, all of them started before the age of 18. While some of them remember being forced to start smoking, the typical...
